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Literature summary extracted from
- Novel insights into the mechanisms regulating pro-atrial natriuretic peptide cleavage in the heart and blood pressure regulation proprotein convertase subtilisin/kexin 6 is the corin activating enzyme (2016), Circ. Res., 118, 196-198 .
Application
| EC Number | Application | Comment | Organism |
|---|---|---|---|
| 3.4.21.61 | drug development | PCSK6 may become a reasonable target for the development of drugs able to control high blood pressure by directly modulating pro-ANP cleavage | Homo sapiens |
| 3.4.21.61 | medicine | PCSK6 may become a reasonable target for the development of drugs able to control high blood pressure by directly modulating pro-ANP cleavage and, therefore, increasing endogenous circulating alphaANP levels. Such a therapeutic approach may reveal beneficial also in the treatment of heart failure | Homo sapiens |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.21.61 | corin + H2O | Homo sapiens | activating processing of corin by enzyme PCSK6 | ? | - |
? |  |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.4.21.61 | Homo sapiens | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.4.21.61 | heart | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.21.61 | corin + H2O | activating processing of corin by enzyme PCSK6 | Homo sapiens | ? | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.4.21.61 | corin activating enzyme | - |
Homo sapiens |
| 3.4.21.61 | PCSK6 | - |
Homo sapiens |
| 3.4.21.61 | proprotein convertase subtilisin/kexin 6 | - |
Homo sapiens |
General Information
| EC Number | General Information | Comment | Organism |
|---|---|---|---|
| 3.4.21.61 | malfunction | lack of PCSK6-dependent corin activation leads to hypertension. PCSK6-mediated processing of corin is reduced in the presence of corin variants T555I and Q568P previously associated to hypertension and to heart disease | Homo sapiens |
| 3.4.21.61 | physiological function | the enzyme is involved in pro-atrial natriuretic peptide (pro-ANP) processing in the heart, key functions of PCSK6 are in the cardiovascular system to control blood pressure homeostasis | Homo sapiens |
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Release 2023.1 (January 2023)
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